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Probenecid: MRP Inhibitor Transforming Tumor and Neuro Re...
2025-10-21
Probenecid brings unique versatility as an MRP and pannexin-1 channel inhibitor, enabling breakthrough studies in multidrug resistance reversal and neuroprotection. Its multimodal actions empower researchers to dissect transporter biology, immunometabolic reprogramming, and inflammation with precision that few reagents can match.
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Probenecid: MRP Inhibitor & Chemosensitizer for Tumor Res...
2025-10-20
Probenecid stands out as a robust MRP inhibitor and chemosensitizer, uniquely enabling researchers to reverse multidrug resistance and dissect transporter biology in tumor and neuroinflammatory models. Its multifaceted inhibition of organic anion transport, pannexin-1 channels, and the calpain-cathepsin pathway empowers advanced experimental designs and translational breakthroughs.
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Probenecid at the Crossroads: Mechanistic Insights and St...
2025-10-19
This thought-leadership article unpacks the multifaceted mechanisms by which Probenecid, an inhibitor of organic anion transporters, multidrug resistance-associated proteins (MRPs), and pannexin-1 channels, is redefining translational research in oncology and neuroscience. Integrating mechanistic insights from recent immunometabolic studies and highlighting strategic guidance for experimental design, the article positions Probenecid as a pivotal tool for overcoming multidrug resistance, probing transporter-immunometabolic crosstalk, and pioneering neuroprotective interventions. By bridging biological rationale, experimental evidence, competitive context, and visionary translational opportunities, this article delivers a forward-looking framework that elevates the conversation beyond standard product literature.
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Liproxstatin-1 and Female-Specific Ferroptosis: A New Par...
2025-10-18
Explore how Liproxstatin-1, a potent ferroptosis inhibitor, illuminates sex-specific mechanisms in iron-dependent cell death pathways. This article offers fresh insights into female-biased ferroptosis and translational applications in renal, hepatic, and salivary models.
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